Revisiting leadership development:the participant perspective

Purpose – The purpose of this paper is to address limitations of prevailing approaches to leadership development programmes and make suggestions as to how these might be overcome. These limitations are an outcome of the dominant rational functional approach to leadership development programmes. Based on empirical research, and underpinned by organisational theory, the paper suggests a shift towards a socio-constructivist perspective on design and implementation of leadership development programmes. The explorative study proposes that context and participant differences need to be recognised as factors impacting on the effectiveness of leadership development initiatives. Design/methodology/approach – The paper is based on a review of relevant literature and qualitative data collected using the case study method. The study presented is explorative. Findings – The paper finds that participant interaction with leadership development programmes varies depending on individual and/or contextual factors. Current design logic neither recognises nor utilises such situatedness as programmes develop their linear and unidirectional logic. Designers of programmes underestimate the extent to which programme participants create a context-specific understanding of leadership learning as they interact with the programme. Their personal and organisational context shapes this interaction. A socio-constructivist perspective can provide theoretical foundation for the argument that leadership development programmes can become more effective if context-specific dimensions are recognised as shaping and constraining factors impacting on programme participants. Originality/value – The paper argues that it is time to move away from offering leadership development programmes which emphasise input over interaction. The paper encourages commissioners and designers of leadership programmes to recognise that an overly didactic approach may limit the effectiveness of such programmes

An experimental analysis of overconfidence in tariff choice

Consumers regularly have to choose between a pay-per-use and a flat-rate option. Due to the increasing number and range of (digital) services, the frequency at which consumers have to make tariff-choice decisions to use these services has become even more prevalent. Prior work has demonstrated that consumers’ tariff choices are often systematically biased and identified overconfidence as one of the key drivers. Yet, prior research is non-experimental and focused on the so-called flat-rate bias. By contrast, we examine the effects of overconfidence on the choice between a pay-per-use and a flat-rate option using an experimental approach. We develop an incentive-compatible experiment to provide causal evidence for the effect of overconfidence on tariff-choice decisions. We find that overconfident (underconfident) consumers underestimate (overestimate) their actual usage, which leads them to choose a pay-per-use (flat-rate) option relatively more frequently. Based on the results, we discuss theoretical and managerial implications as well as avenues for future research

Purification and Identification of a 7.6-kDa Protein in Media Conditioned by Superinvasive Cancer Cells

Background: Selection of the human drug sensitive and invasive cell line (MDA-MB-435S-F) with the chemotherapeutic agent paclitaxel, resulted in the development of drug resistant cell lines displaying enhanced invasion-related characteristics. Materials and Methods: Serum-free conditioned media from the human cancer drug-sensitive and invasive cell line (MDA-MB-435S-F) and its paclitaxel-resistant superinvasive variant (MDA-MB-435S-F/Taxol10p4pSI) were analyzed using Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). Results: A differentially expressed protein was observed at 7.6 kDa, which was 4-fold upregulated in MDA-MB-435S-F/Taxol10p4pSI. The differentially expressed protein was identified using matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometry (MALDI-TOF/TOF MS), as a fragment of bovine transferrin. The transferrin receptor was also found to be overexpressed in the superinvasive cell line. Conclusion: Cleavage of serum proteins such as transferrin could provide a valuable source of markers for malignant tumours and could also play a role in aspects of cancer pathogenesis, such as tumour cachexia

Identification of pancreatic cancer invasion-related proteins by proteomic analysis

Background – Markers of pancreatic cancer invasion were investigated in two clonal populations of the cell line, MiaPaCa-2, Clone #3 (high invasion) and Clone #8 (low invasion) using proteomic profiling of an in vitro model of pancreatic cancer. Materials and methods – Using 2D-DIGE followed by MALDI-TOF MS, two clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with high and low invasive capacities were incubated on matrigel 24 hours prior to analysis to stimulate cell-ECM contact and mimic in vivo interaction with the basement membrane. Results - Sixty proteins were identified as being differentially expressed (>1.2 fold change and p ≤ 0.05) between Clone #3 and Clone #8. Proteins found to have higher abundance levels in the highly invasive Clone #3 compared to the low invasive Clone #8 include members of the chaperone activity proteins and cytoskeleton constituents whereas metabolism-associated and catalytic proteins had lower abundance levels. Differential protein expression levels of ALDH1A1, VIM, STIP1 and KRT18 and GAPDH were confirmed by immunoblot. Using RNAi technology, STIP1 knockdown significantly reduced invasion and proliferation of the highly invasive Clone #3. Knockdown of another target, VIM by siRNA in Clone #3 cells also resulted in decreased invasion abilities of Clone #3. Elevated expression of STIP1 was observed in pancreatic tumour tissue compared to normal pancreas, whereas ALDH1A1 stained at lower levels in pancreatic tumours, as detected by immunohistochemistry. Conclusion - Identification of targets which play a role in the highly invasive phenotype of pancreatic cancer may help to understand the biological behaviour, the rapid progression of this cancer and may be of importance in the development of new therapeutic strategies for pancreatic cancer

Identity Confidentiality in 5G Mobile Telephony Systems

The 3rd Generation Partnership Project (3GPP) recently proposed a standard for 5G telecommunications, containing an identity protection scheme meant to address the long-outstanding privacy problem of permanent subscriber-identity disclosure. The proposal is essentially two disjoint phases: an identification phase, followed by an establishment of security context between mobile subscribers and their service providers via symmetric-key based authenticated key agreement. Currently, 3GPP proposes to protect the identification phase with a public-key based solution, and while the current proposal is secure against a classical adversary, the same would not be true of a quantum adversary. 5G specifications target very long-term deployment scenarios (well beyond the year 2030), therefore it is imperative that quantum-secure alternatives be part of the current specification. In this paper, we present such an alternative scheme for the problem of private identification protection. Our solution is compatible with the current 5G specifications, depending mostly on cryptographic primitives already specified in 5G, adding minimal performance overhead and requiring minor changes in existing message structures. Finally, we provide a detailed formal security analysis of our solution in a novel security framework

Pragmatic Authenticated Key Agreement for IEEE Std 802.15.6

The IEEE Std 802.15.6 is the latest international standard for Wireless Body Area Networks (WBANs). The security of communication in this standard is based upon four elliptic-curve based key agreement protocols. These protocols have been shown to exhibit serious security vulnerabilities but surprisingly, do not provision any privacy guarantees. To date, no suitable key agreement protocol has been proposed which fulfils all the requisite objectives for IEEE Std 802.15.6. In this paper two key agreement protocols are presented which, in addition to being efficient and provisioning advance security properties, also offer the essential privacy attributes of anonymity and unlinkability. The protocols are also quantum-safe as they are independent of any public-key based operations. We develop a formal security and privacy model in an appropriate complexity-theoretic framework and prove the proposed protocols secure in this model